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教师介绍
李琦  (食品科学与工程系)

基本信息

职务:

职称:高级工程师

地址:9d303

邮箱:amanadahere@sina.com

个人简介:

李琦,女,工学博士,高级实验师,南京林业大学林产化学加工工程专业毕业。2013年9月参加工作,2022年10月调入轻工与食品学院食品科学与工程系。主要从事糖苷水解酶的挖掘、改造、重组菌的表达及天然活性物质的催化转化方面的研究。目前作为骨干参与国家重点研发计划项目课题1项,国家自然科学基金2项,横向课题2项。在国内外权威期刊发表学术论文20余篇,其中sci文章10篇,ei文章1篇,并获得授权专利4项。先后指导本科生参加国际互联网加竞赛1项,并获一等奖;指导学生参加国家级生命科学竞赛3项,均获得三等奖及以上;指导本科生省级大创项目1项,并验收优秀。

主要研究方向:

糖苷水解酶的挖掘、基因改造

天然活性物质的催化转化

 

研究课题情况:

[1]十四五国家重点研发计划项目课题--竹源活性成分定向转化富集技术与示范(366.60万元,课题秘书)2022.11-2027.10

[2]十三五国家重点研发项目课题任务--典型林源黄酮和萜类物质生物修饰关键技术及其药理活性的研究(84.00万元,2/10)2016.07-2020.12

[3]国家自然科学基金面上项目--嗜热鼠李糖苷酶底物特异性机制及其定向改(76.80万元,2/10)2016.01-2019.12

代表性成果:

[1] zhang, s. ,  lu, c. ,  cao, s. ,  li, q. ,  wu, g. , &  zhao, l. . (2023). efficient production of icariin and baohuoside i fromepimedium foliumflavonoids by fungalα-l-rhamnosidase hydrolysing regioselectively the terminal rhamnose of epimedin c. biotechnology for biofuels and bioproducts, 16(1).

[2]li, q., wang, l.,  fang, x., zhao, l., (2022).highly efficient biotransformation of notoginsenoside r1 into ginsenoside rg1 by dictyoglomus thermophilum β-xylosidase xln-dt. journal of microbiology and biotechnology, 32(4): 447-457.

[3] li, q., ge, l., zheng, d., zhang, x., zhao, l.,(2022). screening and characterization of a gh78 α-l-rhamnosidase from aspergillus terreus and its application in the bioconversion of icariin to icaritin with recombinant β-glucosidase. enzyme and microbial technology, 153: 109940.

[4] li, q.,  chai, c. ,  du, y. ,  cai, j. , &  zhao, l. . (2022).  recombinant laccase production optimization in pichia pastoris by  response surface methodology and its application in the biodegradation  of octyl phenol and 4-tert-octylphenol. catalysis letters(4), 152.

[5] li, q.,  tong, x. ,  jiang, y. ,  li, d. , &  zhao, l. . (2021). improvements in xylose stability and thermalstability of gh39 β-xylosidase from dictyoglomus thermophilum by site-directed mutagenesis and insights into its xylose tolerance mechanism. enzyme and microbial technology, 151, 109921.

[6] li, q.,  jiang, y.,  tong, x.,  zhao, l., &  pei, j. . (2021). co-production of xylooligosaccharides and xylose from poplar sawdust by recombinant endo-1,4-β-xylanase and β-xylosidase mixture hydrolysis. frontiers in bioengineering and biotechnology, 8, 637397.

[7] li, q., jiang, y., tong, x., pei, j., xiao, w., wang, z., zhao, l.,(2020) .cloning and characterization of the β-xylosidase from dictyoglomus turgidum for high efficient biotransformation of 10-deacetyl-7-xylosltaxol. bioorganic chemistry, 94.

[8] li, q., wu, t., duan, y., pei, j., zhao, l.,(2019). improving the thermostability and ph stability of aspergillus niger xylanase by site-directed mutagenesis. applied biochemistry and microbiology, 55(2).

[9] li, q., wu, t., zhao, l., pei, j., wang, z., xiao, w.,(2018). highly efficient biotransformation of astragaloside iv to cycloastragenol by sugar-stimulated β-glucosidase and β-xylosidase from dictyoglomus thermophilum. journal of microbiology & biotechnology.

[10] li, q., wu, t., qi, z., zhao, l., pei, j., tang, f.,(2018). characterization of a novel thermostable and xylose-tolerant gh 39 β-xylosidase from dictyoglomus thermophilum. bmc biotechnology, 18(1), 29.

 

 

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